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Isolation and Antifouling activity of Azulene Derivatives from the Antarctic Gorgonian Acanthogorgia laxa

Résumé : Three azulenoid sesquiterpenes (1- 3) were isolated from the Antarctic gorgonian Acanthogorgia laxa collected by bottom trawls at –343 m. Besides linderazulene (1), and the known ketolactone 2, a new brominated C-16 linderazulene derivative (3) was also identified. This compound has an extra carbon atom at C-7 of the linderazulene framework. The antifouling activity of compounds 1 and 2 was assayed in the laboratory with Artemia salina larvae, and also in field tests, by incorporation in soluble-matrix experimental antifouling paints. The results obtained after a 45 days field trial of the paints, showed that compounds 1 and 2 displayed good antifouling potencies against a wide array of organisms. Compound 3, a benzylic bromide, was unstable and for this reason was not submitted to bioassays. Two known cembranolides: pukalide and epoxypukalide, were also identified as minor components of the extract. This article is protected by copyright. All rights reserved.
Domaine de référence : Antifouling
Auteur Patiño C Laura P., Manfredi Rodrigo Quintana, Pérez Miriam, García Mónica, Blustein Guillermo, Cordeiro Ralf, Pérez Carlos D., Schejter Laura, Palermo Jorge A.
Année de parution : 2017.
Mots-clés : Acanthogorgiidae, antifouling activity, azulene sesquiterpenoids, marine natural products, Octocorals.
Type de document : Article de revue.
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Ce projet est financé par le Fonds Européen de Développement Régional, la Région Normandie et le Conseil Départemental de la Manche.